Pioneering Research Shows How to Escape from Depression

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Felice Jacka PhD

Felice Jacka PhD is a trailblazing researcher at Deakin University in Australia who is calling the world’s attention to the powerful impact of food on mood. On January 30, 2017, the journal BMC Medicine published her new randomized controlled study called The SMILES Trial. This groundbreaking research demonstrates for the first time that people with moderate to severe depression can improve their mood by eating a healthier diet.

You may be surprised to hear that this kind of study has never been done before, probably because you have read headlines in the past proclaiming that healthier diets decrease risk for depression. We have Professor Jacka and her team to thank for many of those hopeful headlines. Over the past seven years, she published numerous epidemiological (survey-based) studies suggesting that people who report eating an unhealthy diet are more likely to be depressed. However, since these studies were based on questionnaires and weren’t actual diet experiments, they didn’t have the power to PROVE that unhealthy diets CAUSE depression, and couldn’t prove that healthy diets could TREAT depression. These were simply educated guesses that hadn’t been tested in the real world yet. Until now.

Professor Jacka boldly went where no one has gone before: she tested her theories on actual people with clinical depression…and emerged victorious.

The Study

deproProfessor Jacka’s team recruited 67 men and women with moderate to severe depression who reported eating a relatively unhealthy diet. Most were taking antidepressants and/or were in regular psychotherapy.

They put half of these depressed people on a modified Mediterranean diet (aka the “ModiMed” diet—more details below) and required them to attend dietary support sessions with a nutritionist.

The other half continued eating their usual unhealthy diet, but were required to attend social support “befriending” sessions.

Before and after the 12-week study, everyone’s depression symptoms were graded using several different tests. The test this research group chose to focus on was the MADRS scale (Montgomery–Åsberg Depression Rating Scale), which rates mood on a scale of 0 to 60, with 60 being the most severely depressed.


Thirty-two percent had scores so low that they no longer met criteria for depression…


After 12 weeks, people in the ModiMed diet group saw their MADRS scores improve on average by about 11 points. Thirty-two percent (10 out of 31 completers) had MADRS scores so low that they no longer met criteria for depression—remission!

People in the unhealthy diet group improved by only about 4 points on the MADRS test and only 8% (2 of 25 completers) achieved remission.

More happy details:

Cpsssalories were not restricted and body weight stayed about the same for everyone in the study, so people didn’t have to lose weight to feel better.

Surprisingly, the ModiMed diet cost about 19% less than the standard unhealthy diet.

The diet plan was apparently easier to stick to than the social support plan, since more people in the diet group (31 out of 33) made it all the way to the end of the study, compared to only 25 out of 34 people in the support group.

What is the ModiMed diet?

  1. Encouraged foods: whole grains, fruits, vegetables, legumes, low-fat/ unsweetened dairy, raw unsalted nuts, lean red meat, chicken, fish, eggs, and olive oil.
  2. Discouraged foods: sweets, refined cereals, fried food, fast food, processed meat.
  3. Beverages: maximum two sugar-sweetened beverages per week and maximum two alcoholic drinks per day, preferably red wine.

So, what is so special about the ModiMed diet?

Well, THAT is the $64,000 question, and the answer is? We don’t know.

It could be that this diet was higher in some potentially magical ingredient like olive oil or nuts.

It could be that this diet was lower in some potentially evil ingredient like processed meat or refined carbohydrates.

It could be both.

My opinion, based on everything I know about food and the brain, is that this diet is better than the average diet because:

  • healthIt is extremely low in refined carbohydrates (sugar, flour, refined cereals, etc). These non-foods put your blood sugar, insulin, hormones, and neurotransmitters on a dangerous invisible roller coaster. This destabilizes mood and increases risk for insulin resistance, which causes brain damage over time.
  • It contains plenty of natural fat and cholesterol, which the brain needs to function properly [in my opinion the ModiMed diet unnecessarily limits saturated animal fats].
  • It is low in processed oils from seeds such as cottonseed, safflower and corn. These industrially-refined oils are very high in omega-6 fatty acids, which tilt the brain towards inflammation and away from healing.
  • It contains animal sources of protein, which are rich in key brain nutrients such as iron, zinc, and vitamin B 12, and free of anti-nutrients, which interfere with protein and mineral absorption.
  • It is based primarily on whole foods, which humans are well-adapted to eating.

ede
Georgia Ede MD
is a psychiatrist for Smith College in Northampton, Massachusetts.

This article appeared in psychologytoday.com on 17 February 2017

One Comments

  • Cindy06 / 03 / 2017Reply

    Thank you for this valuable information. Depression is a dangerous curse.

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